Chris Zou

Hey, I'm Chris. I am a Member of Technical Staff at LatchBio and a PhD student at Stanford Genetics fortunate to be advised by Dr. Anshul Kundaje. I am interested in systems that enable us to model and engineer the physical world, especially biology.

Previously, I worked at Edison Scientific/FutureHouse and Datavant in engineering roles. I studied CS and Biochemistry at Berkeley, where I founded Health Engine and was part of the Accel Scholars program.

If you would like to collaborate or if there's any way I can help you, please reach out at cwzou [at] stanford [dot] edu.

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Research

Find all my published research here.

DNA-PKcs inhibition sensitizes glioblastoma to radiotherapy through reprogramming of tumor cell states and immune microenvironment cell types
David Raleigh, S. John Liu, Nazanin Majd, Christopher Zou, Harrsha Congivaram, Hinda Najem, Mark Youngblood, I-Ching Wang, +16 other authors, John de Groot, Luke Gilbert
We show that DNA-PKcs inhibition radiosensitizes glioblastoma by reprogramming tumor cell states and remodeling immune cell types in the tumor microenvironment.
[Paper]
Porting AlphaGenome to PyTorch
Danila Bredikhin, Alejandro Buendia, Martin Kjellberg, Christopher Zou, Xinming Tu, Anshul Kundaje
A faithful PyTorch port of DeepMind's AlphaGenome, with released weights and verified numerical equivalence to the original JAX model, exposing a simple inference API for variant effect prediction and in silico mutagenesis.
[Blog] [Code]
PantheonOS: An Evolvable Multi-Agent Framework for Automatic Genomics Discovery
Weize Xu, Erwin Poussi, Quan Zhong, Zehua Zeng, Christopher Zou, Xuehai Wang, Yifan Lu, Miao Cui, +24 other authors, Jesse M. Engreitz, Xiaojie Qiu
We develop a multi-agent framework for bioinformatics, including a code evolution module called Pantheon-Evolve.
[Paper] [Website]
Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy
Katie Lin, Christopher Zou, Akane Hubbard, Sasha Sengelmann, Laine Goudy, I-Ching Wang, Rohit Sharma, Joanna Pak, +9 other authors, Mitchel S Berger, S John Liu
We show that transient delivery of a site-specific epigenetic memory editor can induce stable, complete, and multiplexed suppression of target genes for therapeutic application in GBM.
[Paper]
In vivo perturb-seq of cancer and microenvironment cells dissects oncologic drivers and radiotherapy responses in glioblastoma
S. John Liu, Christopher Zou, Joanna Pak, Alexandra Morse, Dillon Pang, Timothy Casey-Clyde, Ashir A. Borah, David Wu, +7 other authors, David R. Raleigh, Luke A. Gilbert
We developed the first in vivo perturb-seq platform in intact tumors, providing a target discovery and data generation tool.
[Paper]

Misc.

Writing I like:

“Frost and Fire”, Ray Bradbury “Letters from China & Stanford”, Dan Wang “Ultimate Glory: A Frisbee Memoir”, Dave Gessner
Material World, Ed Conway
A Gentleman in Moscow, Amor Towles